Best path to CreateSpace

Scrivener allows a great deal of interior design … alternate page headers, special pagination, and so on. Create Space has a template for formatting. Is it better to format as much as possible in Scrivener or to compile a straightforward .doc file and use CreateSpace template?

It depends on how complicated layout you need. If it is only text or if you have pictures as well, a lot of tables, …

? It is all text, a couple of fonts, but all text.