I like to work in Courier 18 but have selected Optima 12 for exporting. This works just fine, except one small issue: other than a general text ruler that has an indent for each new paragraph, I also use a ruler for lists with each item labelled accordingly and the text in line with the list, ie. a the bullet point sits alone to the left and the text is a separate block next to it. This is customary. However, Scrivener is only able to export one ruler setting, which is why my lists look awful after exporting the draft.
While I like Scrivener to change fonts and sizes it should respect the ruler settings!