I have firefox installed for when I want to use some of the extensions (yay webdeveloper!) but for my daily use I use Camino. It has the cookie-blocking and pop-up blocking built in, and the CamiTools extension has FlashBlock and a bunch of other ad-blocking stuff to make browsing more enjoyable.
I love how well Firefox integrates the extensions without cluttering the interface too much. My setup is remarkably powerful yet still clean. In all seriousness, I can appreciate Camino’s prettiness and grasp of the essentials but I always feel like it’s missing something.
E
Camino doesn’t play nice with Devonthink. 
I hate that Safari always ends up with memory leaks (or whatever the techno-jargon is for slowing then tossing the beachball of death), but I’ve gotta put everything in DT, or I know a day will come when I’ll tear my hair out trying to find some review of a book I hated but which was summed up in a gem of a sentence.
–rob