Set Default Note Style

I’m trying to change the default note style, but don’t see anything in the menus or inspector that allows this. “Set As Defaults” at the bottom of the inspector only applies to the Document Settings.
Format>Note Style>Redefine Note Style From Selection seems like it should have an entry for Default, but it does not.
Am I missing something obvious?

The defaults for new notes (and shapes) are found in Preferences. They are there so you can have different defaults for these two things, and also because not all of the settings in there would make sense as defaults.

Is it possible to set a default for a new note and then change the font in the note so there are multiple fonts used?

Each board can have its own font setting, but that is the extent of it.