I use styles for anything I don’t want to compile as-is, and I only use very common fonts. I recommend checking what Amazon uses on their Kindles. I use Bookerly for almost everything (but it could be TNR, Garamond, etc.) and Helvetica for sciFi dialog passed across a 2099 version of the web. When I compile, styles remain unmodified by ordinary compile settings, but I can add an extra step to change those styles in Compile (at the Styles panel for each section layout).